Quick Resources

  Online Support Group & Forum
  Find Doctor / Treatment Center
  Helpful Forms & Charts
  Diet / Iron Content In Foods
  Join Physician Registry

The benefits and distractions of genetic testing

The benefits and distractions of genetic testing

Knowing if you have one, two or some combination of the three mutations of HFe is of great benefit to those who understand risk. The three possible mutations are C282Y, H63D, and S65C.

The benefit of this knowledge is having the opportunity to alter one’s diet, cut back on alcohol, donate blood, and seek regular monitoring of iron levels long before iron can damage vital organs and cause disease.

The distraction comes when genetic testing is done without fully understanding what the HFe genes represent: an adult onset condition. Not all combinations will result in excessive iron accumulation or disease. Very importantly, with the exception of “iron fist” the symptoms associated with iron overload – fatigue, joint pain, and, infertility – liver and heart disease are not specific to hereditary hemochromatosis. Granted, keeping your iron levels within a healthy range is a wise decision whether you have the genes or not.

Genetics is a fascinating field and with the rise in personalized medicine, therapies, and approaches to clinical management. For now, a clinician can use the Iron Disorders Institute Physician Hemochromatosis Reference Handout which is based on inputs from iron experts such as the members of IDI’s Scientific and Medical Advisory Board and clinical researchers at the National Institutes of Health, particularly Dr. Susan Leitman and her team at the Warren G. Magnuson Clinic.

Other genetic iron disorders such as juvenile hemochromatosis can occur in children, but this condition is not HFe related. This is particularly confusing when a child is genetically tested and found to have one or two mutations of HFe. In some cases, a mother’s concern for her child can lead to mistakes. Pediatric ranges for serum ferritin are different from adult ranges. And serum ferritin is not always a reliable indicator of elevated iron, especially in children. A child, for example, can have fairly significant elevated serum ferritin due to a mild earache or infection because serum ferritin rises in response to inflammation just as it does to excess iron. If a child has a fever when iron tests are performed, the results are skewed and a mother can worry that iron levels are rising due to genetics.

A sensitized patient or physician is the first step towards an increased level of knowledge about an iron disorder. Genetic testing of abnormal iron levels, especially serum ferritin, can prompt a complete diagnosis. But then comes the challenge of therapy. As odd as it may sound, a hemochromatosis patient can experience a variety of iron disorders - including a combination of inherited conditions such as beta thalassemia.

Do we need to be genetically tested when iron levels are elevated? IDI calls for iron levels first, then genetic testing with the benefit of a physician and a genetics counselor. Whichever door you enter first remember this: genetics only reveals risk and does not (yet) determine the therapies for iron reduction.  A person’s iron levels dictate this step in clinical management. With a complete set of iron results a trained professional can address iron deficiency (with or without anemia), iron overload, iron avidity, or anemia of inflammatory response—any or all disorders of iron that may be seen in a hemochromatosis patient during the course of clinical management.

*includes fasting serum iron, total iron binding capacity, serum ferritin and hemoglobin. Some doctors will include transferrin and not the transferrin-iron saturation percentage (TS%) which is a calculation of serum iron divided by TIBC X 100% and is an indirect measurement of transferrin. UIBC also may be seen on lab tests; it too provides an indirect measurement of transferrin.
Note: if you are presently using the healtheiron.com provision, the turn-around time is 5-7 business days. This has to do with the analysis of transferrin.

Other resources on genetics and iron disorders

Genetics worksheets: http://www.irondisorders.org/genetics/

The National Society of Genetic Counselors: http://www.nsgc.org/

Health-e-Iron: http://www.healtheiron.com/hereditary-hemochromatosis

Diet for hemochromatosis: http://www.irondisorders.org/diet/

Recommended reading: links are provided where full text is available

Bacon, Adams, Kowdley, Powell and Tavill. American Association for the Study of Liver Diseases (AASLD) 2011 Practice Guidelines. http://www.aasld.org/sites/default/files/guideline_documents/Hemochromatosis2011.pdf

Feldman AG, Whitington PF. Neonatal hemochromatosis. Journal of Clinical and Experimental Hepatology. 2013 (4): 313-20.

Hulihan MM1, Sayers CA, Grosse SD, Garrison C, Grant A. Iron overload: What is the role of public health? American Journal of Preventive Medicine. 2011 41(6 Suppl 4):S422-7.

Mainous AG 3rd, Knoll ME, Everett CJ, Hulihan MM, Grant AM, Garrison C, Koenig G, Sayers C, Allen KW. A national survey of hemochromatosis patients. Journal of the American Board of Family Medicine. 2012 Jul-Aug; 25(4):432-6. https://www.ncbi.nlm.nih.gov/pubmed/22773711

Sivakumar M, Powell L. Management of human factors engineering-associated hemochromatosis: A 2015 update. World Journal of Hepatology. 2016 Mar 18;8(8):395-400.

Steinberg KK, Cogswell ME, Chang JC, Caudill SP, McQuillan GM, Bowman BA, Grummer-Strawn LM, Sampson EJ, Khoury MJ, Gallagher ML. Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. JAMA. 2001 285(17):2216-22.

Weinberg ED. Iron availability and infection. Biochimica et Biophysica Acta 2009 Jul;1790(7):600-5.

Weinberg, ED. Hazards of iron loading. Metallomics 2010 (2): 732-40.

55 comments (Add your own)

1. http://penessays.com/ wrote:
This article was amazing, thanks for sharing! I have one interesting book dedicated to the topic of genetic tests, follow the link http://penessays.com/

Thu, December 29, 2016 @ 9:14 AM

2. money cheat gta 5 wrote:
So finally we used this tool for generation of money of grand theft auto.

Sat, January 7, 2017 @ 4:27 AM

3. <a href="http://stmkeyscodes.net">steam wallet generator</a> wrote:
You can find steam gift cards and wallet codes at retail stores across the world in a variety of denomination. you can buy unlimited games and get more codes to keep shopping every time a sale.

Sun, February 12, 2017 @ 8:26 PM

4. steam wallet generator wrote:
Youcanfindsteamgiftcardsandwalletcodesat.youcanbuy generator unlimited games and get more codes to keep shopping every time a sale.

Sun, February 12, 2017 @ 8:29 PM

5. steam wallet generator wrote:
you can find steam gift cards and wallet codes steam wallet generator at retail stores across the world in a variety of denomination.

Sun, February 12, 2017 @ 8:32 PM

6. python quiz wrote:
That’s what I was looking for. Very nice blog indeed, thank you admin

Thu, March 23, 2017 @ 4:53 AM

7. Website wrote:
I was impressed with the site that you created, so memotipasi many people to be more advanced, there also Nike Zoom All Out Flyknit Uomo me, as a comparison.

Fri, July 14, 2017 @ 2:18 AM

8. zapatosports wrote:
Your site is truly intriguing zapatos sports and motivation to numerous. I’ll looking forward for a greater amount of your posts. Keep it up!

Thu, November 16, 2017 @ 9:29 PM

9. Maddie wrote:
This text is well written.

Fri, May 18, 2018 @ 1:13 AM

10. Ella wrote:
It is very nice that you share this with us.

Thu, May 24, 2018 @ 2:38 AM

11. wings io wrote:
I read some articles on this site and I think your blog is really interesting and has great information. Thank you for your sharing.

Fri, May 25, 2018 @ 3:48 AM

12. Treatment of Funds Project Help wrote:
By Visiting This Site I Found Cool Stuff Here Keep It Up. https://www.finance-assignments.com/treatment-of-funds-3071

Fri, May 25, 2018 @ 10:26 PM

13. Clarie wrote:
This article gives a lot to think about.

Tue, May 29, 2018 @ 6:56 AM

14. vex 3 wrote:
Great, thanks for sharing this useful information
[url=http://vex-3.com]vex 3[/url]

Sun, June 10, 2018 @ 10:58 PM

15. maria wrote:
t is superb content I thought and even I was searching similar this subject articles for knowing about it.

Tue, June 19, 2018 @ 4:02 AM

16. Meredith Reese wrote:
My husband is my hero, he saved our marriage and my heart from an unhealthy emotional attachment with my ex.
The problem was that I jumped into marriage from a fresh breakup, I never allowed my heart to heal, that’s why I was heavily hunted and distracted to a point that I almost abandoned my husband and our 2 beautiful daughters to my ex. Look how stupid I was to think that my beloved husband of 5 years can be replaced by a bad ass ex-boyfriend.
My husband proved that real men still exist despite all the embarrassment I brought to him, he didn’t let go, he rather worked with Dr. Wakina through his love spell to untie me from the unhealthy emotional attachment with my ex.
Now my eyes are open to cherish the beautiful family I have, I also realised the meaning of true love. I’m hoping to do more than what Dr. Wakina via dr.wakinalovetemple@gmail.com did for me.
Thanks to my husband for letting me share this story.
Remain blessed.

Mon, July 16, 2018 @ 1:59 PM

17. clouds wrote:
My mum had small cell terminal lung cancer. She lost her hair while going through chemo and it devastated. She has recently finished her radiotherapy and she was losing her hair again :( mum wanted me to shave it off again as it's coming out in clumps.i know she was very upset and have told her to be confident it'll grow back but she's so upset, life became hell for me, because i just cant imagine my mum this way. i actually posted this online, and somebody replied me, that he knows once who can cure my mum, without spending much money and without taking anytime anymore, and there wont be any hair loss anymore. I said okay and i want to give it a try, the person that helped him (the person that i was referred to) is Dr Covenant, his email is covenantsolutiontemple@gmail.com, he gave me his email address and i contacted him and told him everything, he (Dr Covenant) said i should not worry everything'll be okay in space of 8 days, i actually gave him a try.
It was not up to the 3rd day, i started noticing changes in my mum. Now my mum is healthy back and the cancer is gone. Am so grateful about this. I actually thought that my mum was going to die, but now she is still alive. Friends, if you have any problem such as cancer, or other illness like HIV/AIDS, GONORRHEA, or any other illness at all, and he is also specialized in getting ex back contact Dr Covenant on his email covenantsolutiontemple@gmail.com or add him on watsapp on +2349057353987 or call him directly on +2348146671563. you can also go through his website if interested http://covenantspelltemple.blogspot.com.

Wed, July 25, 2018 @ 12:31 PM

18. happy wheels wrote:
But then comes the challenge of therapy. As odd as it may sound, a hemochromatosis patient can experience a variety of iron disorders - including a combination of inherited conditions such as beta thalassemia.

Thu, August 2, 2018 @ 1:10 AM

19. <a href="https://www.google.com">Google</a> wrote:
Useful post content. You have provided exceptional info about registered camp sites. I am appreciated your brilliant work. I am looking forward for your next helpful content.

Thu, August 2, 2018 @ 6:13 AM

20. John smith wrote:
[link:http://www.google.com]your link text[/link]

[link="http://www.google.com"] google [/link]

[url=http://www.google.com] google[/url]



[[http://www.google.com|google ]]

[http://www.google.com google ]

[a=http://www.google.com] google[/a]


Thu, August 2, 2018 @ 6:15 AM

21. 1 dollar hosting wrote:
I've read this post and if I could I desire to suggest you some interesting things or suggestions. Perhaps you could write next articles referring to this article. I want to read more things about it!

Thu, August 2, 2018 @ 6:18 AM

22. <a href="https://driverpacksolutiononline.com/"> driverpacksolutiononline.com </a wrote:
Get the full solution to your windows

Tue, August 7, 2018 @ 12:20 PM

23. <a href="https://driverpacksolutiononline.com/"> driverpacksolutiononline.com </a wrote:

Tue, August 7, 2018 @ 12:21 PM

24. <a href="http://www.google.com "> google </a> wrote:
dfmlvkfkvb,b dfgbm;

Thu, August 9, 2018 @ 5:54 AM

25. [link="http://www.google.com"] google [/link] wrote:

Thu, August 9, 2018 @ 5:55 AM

26. [google](http://www.google.com) wrote:

Thu, August 9, 2018 @ 5:56 AM

27. Online Assignment Help wrote:
Students could often find it tough to write their academic tasks. It could lead to them not getting desired grades in the academics. Opting for our Online Assignment Help could be ideal for such students and they can get a complete assignment solution from us.

Mon, October 1, 2018 @ 6:52 AM

28. Homepage wrote:
The best advice is to check out the homepage and get a lot more followers for Instagram

Tue, October 2, 2018 @ 7:38 AM

29. Online Assignment Writer wrote:
Time of gathering is by all accounts something worth being thankful for however, no understudy can use it.

Wed, October 17, 2018 @ 12:20 AM

30. comptable jarry wrote:
Great post! I am actually getting ready to across this information, is very helpful my friend.

Wed, October 17, 2018 @ 1:10 AM

31. visit us wrote:
It is so commendable hence I am going to bookmark it.

Wed, October 24, 2018 @ 10:09 PM

32. http://www.chiefpapers.com/ wrote:
Genetic testing allows the genetic diagnosis of vulnerabilities to inherit diseases, and can also be used to determine a person's ancestry. Normally, every person carries two copies of every gene, one inherited from their mother, one inherited from their father.

Thu, October 25, 2018 @ 8:39 AM

33. movie leather jacket wrote:
In the present study we have investigated whether HFE gene polymorphism may play a role in the disease process of Croatian and Slovenian MS patients and their potential genetic
susceptibility to MS.

Fri, October 26, 2018 @ 1:30 AM

34. dissertation proposal writing service wrote:
Glad to see this brilliant article, You are giving a motivation, an inspiration to us. The content you published here is extremely incredible. It helped me a lot to cheer me up. Thanks for your effort and support for us, Keep Sharing always such types of thing. Loved your Blog!!

Fri, November 16, 2018 @ 4:36 AM

35. click here wrote:
Thank you for sharing with us your knowledge about the benefits and distractions of genetic testing.

Wed, November 28, 2018 @ 7:47 AM

36. http://www.getbodyinshape.net/ wrote:
I'm glad to find this information. Thank you for updating

Fri, January 18, 2019 @ 8:00 PM

37. Assignment Writing Service wrote:
I Appreciate Your Efforts In Preparing This Post. I Really Like Your Blog Articles.

Mon, January 21, 2019 @ 11:32 PM

38. Accounting Assignment Help Uk wrote:
By Visiting This Site I Found Cool Stuff Here Keep It Up.

Tue, January 22, 2019 @ 12:02 AM

39. Assignment Expert wrote:
Thanx For Sharing Such Useful Post Keep It Up :)

Tue, January 22, 2019 @ 12:15 AM

40. Assignment Help Online wrote:
Such A Nice Post, Keep Providing Good Resources.

Tue, January 22, 2019 @ 12:27 AM

41. Harvard Case Solutions wrote:
Good Way Of Telling, Good Post To Take Facts Regarding My Presentation Subject Matter, Which I Am Going To Deliver In My College

Tue, January 22, 2019 @ 12:49 AM

42. Case Study Writing Services wrote:
Those Who Come To Read Your Article Will Find Lots Of Helpful And Informative Tips

Tue, January 22, 2019 @ 1:00 AM

43. Case Study Help wrote:
I'm Getting Excited About This Kind Of Beneficial Information Of Your Stuff In The Future

Tue, January 22, 2019 @ 1:12 AM

44. Writing A Case Study wrote:
Get The Dissertation Writing Service Students Look For These Days With The Prime Focus Being Creating A Well Researched And Lively Content On Any Topic.

Tue, January 22, 2019 @ 1:24 AM

45. Case Study Solution wrote:
Things Are Very Open And Intensely Clear Explanation Of Issues. Was Truly Information. Your Website Is Very Beneficial.

Tue, January 22, 2019 @ 1:36 AM

46. Harvard Case Analysis wrote:
This Is Great Information For Students. This Article Is Very Helpful I Really Like This Blog Thanks. I Also Have Some Information Relevant For Online Dissertation Help.

Tue, January 22, 2019 @ 1:47 AM

47. Case Study Help wrote:
My Friend Recommended This Blog And He Was Totally Right Keep Up The Good Work

Tue, January 22, 2019 @ 3:25 AM

48. Case Answer wrote:
Science Channel’s Are Giving A Complete Knowledge To Its Viewers About Every Thing Students Write Done Dissertation On This Subjects And Show Its Importance.

Tue, January 22, 2019 @ 3:37 AM

49. Case Study Solution wrote:
We Also Share Some Information About Our Business

Tue, January 22, 2019 @ 3:54 AM

50. Computer Science Assignment Help wrote:
I Personally Like Your Post, You Have Shared Good Article. It Will Help Me In Great Deal.

Tue, January 22, 2019 @ 4:21 AM

51. Content Writing Service wrote:
Great Information,It Has Lot For Stuff Which Is Informative.I Will Share The Post With My Friends.

Tue, January 22, 2019 @ 4:40 AM

52. Coursework Project Help wrote:
I Appreciate This Work Amazing Post For Us I Like It.

Tue, January 22, 2019 @ 6:18 AM

53. Happy Wheels wrote:
great article, I was very impressed about it, wish you would have stayed next share

Tue, January 29, 2019 @ 12:47 AM

54. kissmanga wrote:
I am very happy to read this. Appreciate your sharing

Tue, January 29, 2019 @ 12:47 AM

55. Hostgator Coupons wrote:
I could feel the equivalent exploratory experience while perusing. The writer could compose inside a short and adorable sentence. As I would see it a large portion of youth and young people squandering their time by futile visiting and perusing recordings. You need to compose to help the advanced world.

Wed, February 20, 2019 @ 5:03 AM

Add a New Comment


Comment Guidelines: No HTML is allowed. Off-topic or inappropriate comments will be edited or deleted. Thanks.