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Restless legs syndrome: a community-based study of prevalence, severity, and risk factors.


Restless legs syndrome: a community-based study of prevalence, severity, and risk factors.

In a cross-sectional study of 701 individuals ages 50-89 years to assess the prevalence and severity of Restless Legs Syndrome (RLS), investigators report that  the serum iron, transferrin and ferritin were similar in RLS and non-RLS patients, but the soluble transferrin receptor (sTR) concentrations were higher in subjects with and without RLS. Female sex and high sTR independently predicted the risk of RLS. A high sTr indicates increased iron turnover.

Neurology. 2005 Jun 14;64(11):1920-4.

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29 comments (Add your own)

1. Jeff wrote:
above, I have had RLS ever since I broke my back at the age of 14. Was not diagnosed with it until I was in my 30 s. many, many peploe still cannot get a dfinitive diagnosis, and we ( RLS patients) deal with all kinds of medical personnel who do not believe RLS even exists. They will not medicate us properly, etc. I am one of the lucky ones, I guess, since I have educated myself thoroughly about RLS, and I never take no for an answer. None of the approved meds work for me or many others for that matter, and can actually cause augmentation of symptoms. (see Margo's post). The only thing that stops MY RLS is a good dose of Vicodin and morphine. Otherwise it would be haunting me 24/7. I have lots of chronic pain issues, so I was on pain meds anyway. All of the RLS meds have very undesirable side effects, besides the augmentation, for me and alot of others. We simply cannot take them! We also have to put up with peploe who think RLS is disease made up by the drug companies to sell drugs. that is so beyond ridiculous, and I cannot believe that after all this time that we still have to deal with this. No one makes jokes about diabetics, or peploe with heart disease, etc, but both of these can happen to a severely sleep deprived person.RLS was first described in the 1600 s by Sir Thomas Willis, and was actually named by a Swedish doctor named Ekbom, so it is also called Ekbom Disease/ or Willis Ekbom Disease. I am quite SURE that there were NO TV ads for Requip in the 40 s, so we knew we had RLS waaaay before those were ever aired. so, my question to you, as a doctor, what was you purpose in posting this on your blog site. I NEED to know WHY, and will not stop asking until I get a straight answer. That is a promise, for sure.Like I said you have stirred up a hornet's nest. What kind of peploe actually read your blog? I never would have heard have even heard of it, if it had not popped up in my email under my RLS alerts . so, what kind of audience are you targeting here? I was thinking about it all night, because I obviously was not sleeping, so I have a lot more to say, but will stop for now. I just want to know WHY. We have plenty of places we can post about RLS, so I should at LEAST thank you for putting up some of the comments you rec'd. Maybe someone who does not think RLS is a real disease will read these. It still does NOT tell us what YOU think about RLS and treating it. We deserve to know WHY, and I will keep asking until you answer me.

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Other medical problems that can contribute to the development of RLS include iron deficiency, Parkinson's disease, renal disease, diabetes, rheumatoid arthritis, and peripheral neuropathy (a nervous system disease affecting nerves in the extremities). Pregnant women often note symptoms of RLS after 20 weeks of gestation, and dialysis patients are especially susceptible to developing RLS. Patients who take antidepressants, sedating antihistamines, or anti-nausea medications may develop RLS.

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