Iron Bytes Home // Iron Library-Resources // Advanced Reading Room // Iron Bytes Iron loading increases cholesterol accumulation and macrophage scavenger receptor I expression in TH Loading of mononuclear phagocytes with iron leads to oxidization of LDL, increased cellular cholesterol accumulation and scavenger receptor expression, and supports the hypothesis that increased macrophage iron levels promote atherogenesis. Metabolism. 2005 Apr;54(4):453-9. Read More Wed, October 21, 2009 (No comments) The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoiet HFE C282Y is a risk factor for hepatic veno-occlusive disease (HVOD) and  carbamyl-phosphate synthetase (CPS) polymorphisms may counteract its adverse effects. Bone Marrow Transplant. 2005 April 18. Read More Wed, October 21, 2009 (No comments) Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly Subjects aged 65-99 years were followed for up to 10 years to assess dietary and serum vitamins and minerals for prediction of acute myocardial infarction (AMI) and stroke.  Low intakes of vitamin D, flavonoids and low serum iron* were predictors of AMI.  Comment: *serum iron is lowered in patients with anemia of chronic disease (ACD), which is not a condition of iron deficiency, but of iron withholding. Nutrition, Metabolism and Cardiovascular Disease. 2005 Jun;15(3):188-97. Read More Wed, October 21, 2009 (No comments) Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases. Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease. MRI can be used to measure brain ferritin iron to target high-risk populations prior to symptom onset. Annals New York Academy of Sciences 2004 Mar;1012:224-36. Read More Wed, October 21, 2009 (3 comments) Regulation of Hfe by stress factors in BV-2 cells. Mutations of HFE, the iron loading gene, can be a risk factor for Alzheimer’s disease. Neurobiology Aging. 2005 Jun;26(6):803-12. Read More Wed, October 21, 2009 (2 comments) Mutations in the hemochromatosis gene (HFE) and multiple sclerosis. Multiple Sclerosis patients carrying the mutant C282Y allele of HFE, the iron loading gene exhibited earlier onset of disease symptoms relative to other genotypes. Neuroscience Letters 2005 Aug 5;383(3):301-4. Read More Wed, October 21, 2009 (1 comment) Serum ferritin, transferrin and soluble transferrin receptor levels in multiple sclerosis patients. The iron indices of 27 patients with MS were studied. Serum transferrin receptor (sTFR) levels found to be significantly higher in chronic progressive active MS. Multiple Sclerosis 2005 Jun;11(3):272-5. Read More Wed, October 21, 2009 (1 comment) Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. In a cross-sectional study of 701 individuals ages 50-89 years to assess the prevalence and severity of Restless Legs Syndrome (RLS), investigators report that  the serum iron, transferrin and ferritin were similar in RLS and non-RLS patients, but the soluble transferrin receptor (sTR) concentrations were higher in subjects with and without RLS. Female sex and high sTR independently predicted the risk of RLS. A high sTr indicates increased iron turnover. Neurology. 2005 Jun 14;64(11):1920-4. Read More Wed, October 21, 2009 (No comments) Navigate Contact Us DVD Chronic Diseases Affected by Iron In Memorium Iron Blog About Us Our Boards For Patients For Medical Professionals About Iron Iron Disorders Iron Library-Resources Learning More Advanced Reading Room Articles Iron Bytes Bibliographies Position Papers Opinion Information Brochures Genetics Order Materials Symptoms Therapies Receive Updates Diet Order Iron Tests Give